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  Ester Valls, PhD
  
  Post-Doctoral Fellow

Ester received her PhD degree in Molecular Biology from Universitat de Barcelona / Institut de Biologia Molecular de Barcelona in 2006. The same year she moved to New York and joined Melnick's lab for her post-doctoral training. She is studying the role that LRF plays in lymphomagenesis and normal B cell development. LRF is a member of the BTB/POZ - ZF family of transcriptional factors and is able to interact with BCL6, another BTB-ZF protein that plays important roles in normal B-cell development and malignant transformation. Her hypothesis is based on a cooperative role between LRF and BCL6 controlling critical pathways in lymphomagenesis and during progression of different stages of normal B cell development. In order to elucidate the mechanisms underlying this cooperation, she is using high-throughput techniques (ChIP-on-ChIP and siRNA GE arrays) in combination with functional assays to identify new target genes co-regulated by this two proteins.