The coordinated actions of transcription factors in concert with the epigenetic structuring of chromatin determine the phenotype of cells during development and homeostasis in multicellular organisms. Perturbation of transcriptional and epigenetic regulatory complexes accordingly play a fundamental role in malignant transformation. The goal of our research group is to understand the mechanisms through which transcriptional and epigenetic regulation occur during normal differentiation and how these processes become disrupted in human cancers, and to use this information to develop specific and potent therapeutic strategies. The particular tumors that we study are leukemias, lymphomas and breast cancer.